THE HIGH AFFINITY PERIPHERAL BENZODIAZEPINE RECEPTOR LIGAND DAA1106 BINDS TO ACTIVATED AND INFECTED BRAIN MACROPHAGES IN AREAS OF SYNAPTIC DEGENERATION: IMPLICATIONS FOR PET IMAGING OF NEUROINFLAMMATION IN LENTIVIRAL ENCEPHALITIS

HIV encephalitis (HIVE) is characterized by neurodegeneration mediated by toxins derived from infected and activated brain macrophages.Since the peripheral benzodiazepine receptor (PBR) is abundant on brain macrophages, we hypothesized that [3H]DAA1106, a new PBR ligand, can label infected and activated brain macrophages in HIVE.Using cell culture

Background: The human-opossum (Didelphis marsupialis) conflict has increased during the last decades mainly due to natural habitat loss, and mediated by generalist and opportunistic habits of altitude sunscreen opossums.A potential solution to reduce this conflict is to discourage the presence of opossums in human settlements without affecting the

Natural killer (NK) cells, with a unique NK cell receptor phenotype, are abundantly present in the non-pregnant (endometrium) and pregnant (decidua) humanuterine mucosa.It is hypothesized that NK cells in the endometrium are precursors for decidual NK cells present during pregnancy.Microenvironmental changes can alter the phenotype of NK cells, but